Work

Misfolding CPA1 mutation accelerates precancerous pancreas lesions in KC mice

Year: 2025

Type: article

Abstract: Inborn mutations in the CPA1 gene encoding carboxypeptidase A1 have been proposed to increase the risk of pancreatic ductal adenocarcinoma (PDAC) by causing enzyme misfolding and endoplasmic reticulum stress in the pancreas. Here, we demonstrated in a novel mouse model that a misfolding Cpa1 mutation accelerated the development of precancerous lesions driven by mutant Kras in the pancreas. The observations offer experimental support for the notion that CPA1 mutations are risk factors for human PDAC.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00025.2025

Authors: Alexandra Demcsák, Miklós Sahin-Tóth

Institution: University of California, Los Angeles

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Hirshberg Foundation for Pancreatic Cancer Research, National Institute of Diabetes and Digestive and Kidney Diseases