Work

Intervention effect of curcumin on sepsis-associated acute kidney injury via regulation of p300 expression and protein lactylation

Year: 2025

Type: article

Abstract: This study investigates the protective effects and underlying mechanisms of curcumin in sepsis-associated acute kidney injury (SA-AKI). Using a cecal ligation and puncture (CLP) model to simulate SA-AKI, our results demonstrate that curcumin significantly reduced serum creatinine and urea nitrogen levels, alleviated tubular damage and inflammation, improved cellular activity, and inhibited apoptosis. Further analysis revealed that curcumin inhibited the expression of p300 and decreased protein lactylation modification in renal tissue, thereby exerting anti-inflammatory and antioxidant effects. These findings suggest that curcumin may have potential therapeutic value for the prevention and treatment of SA-AKI.

Source: BMC Immunology

DOI: 10.1186/s12865-025-00750-3

Authors: Mengyuan Luo, Quanmang Zhu, Guangcai Xu, Dan Liu, Jiajun Xiao, Qiqing Shi

Institution: Fudan University

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090