Each nephron is worth every heartbeat: navigating acute kidney injury in children post-cardiac surgery
Year: 2025
Type: article
Abstract: Cardiac Surgery-associated acute kidney injury (CS-AKI) is a common complication in children. Comparison of studies over the last 2 decades has been difficult because of varying definitions and practice heterogeneity. Multiple risk factors exist; however, few are modifiable. Limitations in serum creatinine and urine output have hampered precision in CS-AKI diagnosis. Delineating CS-AKI using durational, biomarker-based, and fluid sub-phenotypes has strengthened associations with outcomes. Despite the significant short and long-term effects of CS-AKI, no study has proven efficacious for its prevention or treatment. Targeted early risk stratification tools should be considered for prognostication and possible clinical trial enrichment. Long-term consequences of CS-AKI need further study, given the inconsistency in findings, through systematic follow-up of these high-risk patients.
Institutions: Meyer Children's Hospital, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, University of Padua, Azienda Ospedale - Università Padova, Cincinnati Children's Hospital Medical Center, University Hospital of Geneva, Children's Hospital Colorado, University of Colorado Anschutz, University of Colorado Denver
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,090
OpenAlex ID: W4414459855