Work

Cu–diamine ligand-controlled asymmetric Henry reactions and their application in concise total syntheses of linezolid and rivaroxaban

Year: 2025

Type: article

Abstract: A Cu-bis(sulfonamide)-diamine complex catalytic system was exploited in asymmetric Henry reactions to construct versatile chiral nitroalcohols with high enantioselectivity from carbamate-acetaldehydes and nitromethane. This elegant approach was further implemented to complete the asymmetric total syntheses of a series of oxazolidone skeleton drugs, such as linezolid (antibiotic) and rivaroxaban (anti-coagulant), in a concise and efficient way.

Source: RSC Advances

DOI: 10.1039/d5ra05795g

Authors: Yiwei Zhang, Wei Xiao

Institutions: Sichuan University, Army Medical University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: National Natural Science Foundation of China, Natural Science Foundation of Chongqing, Centre Scientifique et Technique du Bâtiment