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A Design of Copper(II) Coordination Polymers with l -Homoserine: Structural, Spectroscopic, and Biological Studies

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Five copper(II) coordination polymers─ trans -[Cu(μ- l -hser)( l -hser)] n ( 1a ), { cis -[Cu(μ- l -hser) 2 ]·H 2 O} n ( 1b·H 2 O ), {[Cu(μ- l -hser)(H 2 O)(bpy)] 2 SO 4 ·2H 2 O} n ( 2·2H 2 O ), {[Cu(μ- l -hser)(H 2 O)(bpy)] 2 SO 4 ·3H 2 O} n ( 2·3H 2 O ), and {[Cu(μ- l -hser)(H 2 O)(bpy)] 2 SO 4 ·4H 2 O} n ( 2·4H 2 O )─were synthesized via solution-based and/or mechanochemical methods ( l -hser = l -homoserinate, bpy = 2,2’-bipyridine). The compounds were characterized in the solid state (using single-crystal and powder X-ray diffraction (SCXRD and PXRD), EPR, Raman and IR spectroscopy, and thermogravimetric analysis (TGA)) and in solution (using UV–vis spectroscopy, EPR, Raman spectroscopy, and fluorimetry). In the binary bis(homoserinato)copper(II) compounds, 1a and 1b·H 2 O, polymerization is achieved through the hydroxyl group of the l -homoserinate side chain. In contrast, all ternary compounds ( 2·2H 2 O, 2·3H 2 O, and 2·4H 2 O ) achieved polymerization through the carboxylate group of l -homoserinate. Successful solid-state transformation of 2·2H 2 O into 2·4H 2 O was established at higher relative humidity values. Copper(II) centers adopt a square-pyramidal geometry in 1a and a distorted octahedral geometry in all other investigated compounds. Spectroscopic studies suggest that 1a retains its solid-state geometry in solution, while 2·2H 2 O and 2·3H 2 O exhibit slight changes. Among the compounds, 2·2H 2 O exhibited moderate antiproliferative activity against H460 (lung), MCF-7 (breast), and HCT116 (colon) cancer cell lines, and demonstrated antibacterial activity against Moraxella catarrhalis ATCC 23246. Absorption and fluorescence spectra suggested a lower binding affinity of 2·2H 2 O to the double-stranded DNA dodecamer ds(CGCGAATTCGCG).

Source: ACS Omega

DOI: 10.1021/acsomega.5c05776