Work

Clinical safety of home treatment for pulmonary embolism: a multicenter registry study of the Asian population

Year: 2025

Type: article

Abstract: Background: The short-term safety of home-based management of pulmonary embolism (PE) in Asian patients remains unclear. Objectives: The aim of the study was to assess the 30-day clinical safety of home-based treatment compared with in-hospital treatment in Japanese patients with PE. Methods: In this multicenter retrospective study, we enrolled consecutive patients diagnosed with acute PE from the Heart and Vascular Disease Outcome Study in Saga and Kyushu Region-venous thromboembolism registry, performed in the Saga prefecture, Japan, between 2015 and 2024. Among the 641 registered patients, 104 and 537 were treated at home and in the hospital, respectively. After performing 1:1 propensity score matching, 208 patients were analyzed. The primary composite outcome was 30-day PE-related death, aggravation of venous thromboembolism, and bleeding events. Bleeding events were defined based on the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries criteria as moderate/severe. Results: = .69). Individual components of the primary composite outcome were also comparable. Conclusion: The risk of PE-related events and bleeding in Japanese patients with PE treated at home was comparable to that of patients who received in-hospital treatment.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2025.103194