E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis
Year: 2025
Type: article
Abstract: Balance between microbiota-specific effector and regulatory T (Treg) cells is required to promote intestinal health and limit disease pathology. The pathways regulating T cell equilibrium during inflammation and the role of individual microbiota members in these outcomes are still being established. Here, we demonstrate that colonization with a single adherent-invasive Escherichia coli strain restrains pathogenic microbiota-directed T helper type 1 (Th1) cells. This results in a higher proportion of colon Treg cells, specifically tolerogenic microbiota-specific RORγt + FoxP3 + Treg cells, during intestinal inflammation. This anti-inflammatory shift limits pathology in mouse colitis models. This process requires interleukin-10 production by colon CX 3 CR1 + antigen-presenting cells to suppress microbiota-specific Th1 cells. This work suggests a mechanism for local circuits that control intestinal T cells to limit microbiota-directed pathology.
Source: Cell Reports
Authors: Dasom V. Kim, Amanda Chen, Charles Ng, Lisette Peres-Tintin, Seung-Eun Park, Monica Acosta, Ryann Callaghan, Nikketa Stanford, Miozzottys Perez-Rosario, Dean B. Matthews, Daniel Zegarra-Ruiz, Gretchen E. Diehl
Institutions: Memorial Sloan Kettering Cancer Center, Cornell University
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
Funders: Burroughs Wellcome Fund, Crohn's and Colitis Foundation, Cycle for Survival, National Institutes of Health, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G144785880, G1886068547, G2308033977, G2354209684, G2474591413, G3014393894, G371051372, G4102770861, G4563812999, G5109122429, Regulation of lupus pathogenesis through modulation of thymic development of pathobiont-specific T cells, Regulation of Microbial Trafficking to the Thymus in Early Life, G7660896353, Investigating the Role of the Microbiome in Mononuclear Phagocyte Function, G9000003249, Cancer Center Support Grant, Orchestrating intestinal immunity through microbiota-CX3CR1+ cell interactions, G970892991
OpenAlex ID: W4414478635