Assessment of Biofilm Formation in Extended Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae
Year: 2025
Type: article
Abstract: therapy and promoting antibiotic resistance [1,2].Klebsiella pneumoniae, a commensal bacterium of the human gastrointestinal tract, skin, and nasopharynx, is a major pathogen that causes both community-acquired and nosocomial infections, including urinary and biliary tract infections, septicemia, and pneumonia [3].Biofilm formation in K. pneumoniae [4] involves the aggregation of microbial cells enclosed in a self-produced polysaccharide matrix that adheres to biological surfaces [5].Drug-resistant K. pneumoniae, particularly extended-spectrum β-lactamase (ESBL)-pro- ducing strains, causes a substantial antibiotic management problem in treating patients with infections, thereby increasing mortality rates.ESBL-producing K. pneumoniae isolates have greater potential to form biofilms than non-ESBL producers [1, 4, 6].Most K. pneumoniae isolates expressed two types of fimbrial adhesins (types 1 and 3).Type 1 and 3 fimbriae encoded by the
Source: Laboratory Medicine Online
Authors: Yumi Park, Sun Hoe Koo, Jimyung Kim
Institution: Chungnam National University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4414479218
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