Work

The effect of Moringa oleifera L. extract on total cholesterol levels and cardiac hypertrophy in cigarette smoke-exposed mice: An experimental study

Year: 2025

Type: article

Abstract: Cigarette smoke contains harmful chemicals that induce oxidative stress by increasing the levels of reactive oxygen species (ROS), thereby complicating cardiovascular disease treatment. Moringa oleifera L., rich in secondary metabolites and antioxidants, has shown medicinal potential. This study aimed to investigate the phytochemical composition of M. oleifera and its potential effects on cardiac hypertrophy and total cholesterol levels in mice exposed to cigarette smoke. Thirty male white mice (Mus musculus) were divided into five groups (n = 6). The negative control group received only food and water, whereas the positive control group was exposed to cigarette smoke without M. oleifera extract. Groups 1, 2, and 3 were exposed to cigarette smoke, and M. oleifera extract was administered at doses of 125, 250, and 500 mg/kg body weight (BW) for 14 days. On the fifteenth day, the mice were sacrificed to obtain heart samples and total cholesterol levels were measured. One-way ANOVA followed by a post-hoc test showed that M. oleifera extract significantly affected cardiac hypertrophy and total cholesterol levels in mice exposed to cigarette smoke (p < 0,05). M. oleifera extract significantly affected cardiac hypertrophy and total cholesterol levels in rats exposed to cigarette smoke with p =0,001 and p=0,000, respectively.

Source: AcTion Aceh Nutrition Journal

DOI: 10.30867/action.v10i3.2360

Authors: Mulyati Sri Rahayu, Sri Wahyuni

Institution: Malikussaleh University

Language: English

Topic: Moringa oleifera research and applications

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $52