Long-term exposure to moderate cold reduces incidence of reperfusion tachyarrhythmias in rats
Year: 2025
Type: article
Abstract: Moderate cold acclimation (CA) gradually reduces total reperfusion PVCs and tachyarrhythmia duration in rat myocardium, detectable after 5 wk and lost after a 2-wk recovery. Reduced n-6/n-3 PUFA ratio, protective Cx43 and UCP1 distribution, and increased GPX4 expression supports the antiarrhythmic effect elicited by CA. Mitochondrial antioxidants SOD2 and TXNRD2 are upregulated after just 1 day of exposure. The brown adipose tissue-to-body weight ratio increases during CA, and mitochondrial density exhibits an independent pattern of change.
Source: Journal of Applied Physiology
Institution: Charles University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414485349