Work

An explainable CT-based machine learning model integrating carotid plaque and perivascular adipose tissue for predicting symptomatic plaques

Year: 2025

Type: article

Abstract: Rationale and objectives: Accurate identification of symptomatic carotid plaques remains a clinical challenge, as conventional imaging focuses mainly on luminal stenosis and lacks sensitivity to plaque vulnerability and perivascular inflammation. This study aimed to develop and validate an explainable machine learning model integrating CT-based radiomics features from carotid plaque and perivascular adipose tissue (PVAT) to identify symptomatic carotid plaques. Materials and methods: 324 patients with extracranial carotid atherosclerosis and stenosis who had undergone head and neck computed tomography angiography (CTA) were retrospectively included. Three-dimensional radiomics features were extracted from segmented carotid plaque, PVAT and combined carotid plaque and PVAT (CP-PVAT) regions. Independent clinical factors were identified using univariate and multivariate logistic regression analyses. A combined model integrating the radiomics signature with selected clinical factors was developed. Models were developed and underwent internally validated using five-fold cross-validation to enhance robustness and minimize overfitting. Model interpretability was assessed using Shapley Additive Explanations (SHAP). Results: < 0.05, DeLong's test). SHAP analysis demonstrated that radiomics features provided complementary information, enhancing model interpretability and clinical relevance. Conclusion: This explainable radiomics-based model, combining CP-PVAT features with clinical risk factors, may serve as a promising tool for identifying symptomatic carotid plaques and supporting individualized cerebrovascular risk assessment.

Source: Frontiers in Neurology

DOI: 10.3389/fneur.2025.1679861