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Underlying metabolic syndrome exacerbates Vibrio vulnificus- induced acute kidney injury via systemic Th17/Treg dysregulation

Year: 2025

Type: article

Abstract: This study reveals that high-fat diet (HFD)-induced metabolic dysfunction exacerbates Vibrio vulnificus sepsis-associated acute kidney injury (AKI) via TLR4-driven inflammation, oxidative stress, and systemic Th17/Treg imbalance. Novel in vitro findings show that IL-17 and leptin synergistically activate NF-κB signaling in renal epithelial cells, amplifying inflammation, which is mitigated by IL-17 receptor blockade. These results highlight IL-17 signaling as a potential therapeutic target for reducing AKI severity in obese individuals with bacterial sepsis.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00073.2025

Authors: Madhura Pravin More, Punnag Saha, Subhajit Roy, Ayushi Trivedi, Saurabh Chatterjee

Institution: University of California, Irvine

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Environmental Health Sciences