Work

The Association of Periodontitis With Risk of Prevalent and Incident Metabolic Syndrome

Year: 2025

Type: article

Abstract: AIM: To investigate whether periodontitis is associated with prevalent and incident metabolic syndrome (MetS). MATERIALS AND METHODS: The baseline study included 4183 individuals from a population-based survey (DILGOM) in 2007 and follow-up of 1047 participants with clinical re-examination in 2014. The risk of periodontitis was assessed with saliva biomarkers using a validated, three-group cumulative risk score for periodontitis (CRS I, II and III). RESULTS: In fully adjusted models, CRS III was associated with prevalent MetS (OR: 1.35, 95% CI [1.11-1.65]), high waist circumference (1.55 95% CI [1.26-1.91]), high blood pressure (1.29 95% CI [1.05-1.59]) and the number of MetS components (β: 0.18, 95% CI [0.06-0.30]). Among participants without MetS at baseline (n = 618), 128 (20.7%) developed MetS during follow-up. In the fully adjusted model, CRS III trended positively with incident MetS (RR: 1.55, 95% CI [ 0.96-2.51]) in the whole population and had a significant positive association in women (2.06, 95% CI [1.08-3.94]), and in non-smokers (1.78, 95% CI [1.01-3.14]). The risk between CRS and incident MetS was mediated via systemic inflammation. CONCLUSION: Periodontitis is associated with an increased risk of having metabolic syndrome and, in particular, clearly with the number of MetS components: abdominal obesity, hyperglycaemia and hypertension. Systemic inflammation may elucidate the observed higher risk of incident MetS.

Source: Journal Of Clinical Periodontology

DOI: 10.1111/jcpe.70042