Work

From reactive to proactive: Continuous protein monitoring for preventive health care

Year: 2025

Type: article

Abstract: Continuous biomarker monitoring is revolutionizing chronic disease management, with glucose monitoring for diabetes as the primary example. Given the success of this approach, a transition to continuous protein monitoring (CPM, a real-time, implantable or wearable technology) could similarly advance precision medicine. In this work, we review state-of-the-art CPM platforms and their prospective clinical impact across both chronic disorders-metabolic, cardiovascular, autoimmune, and neurodegenerative-and acute crises, such as sepsis and transplant dysfunction. We also highlight remaining barriers to widespread adoption, including sensor stability, robust machine learning models for live interpretation, and responsible data handling for patient privacy. With continued engineering and clinical validation, emerging biosensor technologies could transform disease management, facilitating earlier interventions and individualizing treatment strategies, ultimately improving patient outcomes.

Source: Science

DOI: 10.1126/science.ady6497

Authors: Jane M. Donnelly, Ryan A. Neff, Andrew J. H. Sedlack, Vuslat B. Juska, Luis Fernando Ayala-Cardona, Joseph Bass, Elizabeth M. McNally, Sanjiv J. Shah, Nabil Alshurafa, Eyal Y. Kimchi, G. R. Scott Budinger, Shana O. Kelley

Institutions: Northwestern University, Chan Zuckerberg Biohub Chicago, University College Cork, Tyndall National Institute, Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1005734346, G2229906039, G2977140659, G3635687262, G3692266691, Microglia mediate cognitive dysfunction in elderly survivors of pneumonia, G3790582476, G389896472, G6201103402, G659096663, G7401112382, G745765282, Continuous monitoring of epidermal inflammatory response to mechanical strain, Delirium Dynamics: Understanding Causes and Effects, Reagentless Sensor Technologies For Continuous Monitoring of Heart Failure Biomarkers, G924531897

OpenAlex ID: W4414494583

FWCI: 5.183

Cites: 151

Cited by: 23

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