Haptoglobin response in serum and pleural fluid of tuberculin reactor cattle assessed by culture and gross pathology
Year: 2025
Type: article
Abstract: Haptoglobin (Hp) serum concentration is a highly sensitive, non-specific indicator of inflammation. In the present study, following the example of studies conducted on humans, we analysed whether haptoglobin concentrations in pleural fluids and sera in tuberculin-reactor cattle could be an additional biomarker of Mycobacterium bovis infection. The clinical material (serum, n =60, pleural fluid, n =80) was collected from 140 dairy cattle ( Bos taurus ) shortly before culling at slaughter. During postmortem examination, organs were assessed for tuberculosis-like lesions and tissue samples were collected from all animals post-mortem for Mycobacterium tuberculosis complex (MTBC) culture. The relationship of Hp serum concentrations in cattle with and without tuberculous and the results of MTBC culture were analysed. Serum samples showed a positive correlation between the Hp concentrations and MTBC culture. However, this phenomenon was not confirmed in pleural fluids. Thus, Hp concentrations in cattle serum can be a useful complementary tuberculosis diagnostic tool in cattle. • Haptoglobin (Hp) concentration in serum correlated with MTBC presence in cattle • Tissue fluid was not an appropriate source of Hp for assessing tuberculosis in cattle • No correlation was demonstrated between Hp concentration in serum and the presence of TB-like lesions
Source: The Veterinary Journal
Authors: Anna Didkowska, Daniel Klich, Katarzyna Matusik, Magdalena Wilczek, Krzysztof Anusz, Monika Krajewska-Wędzina
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,310
Award: G7409454359
OpenAlex ID: W4414498351