Actinomycetoquinones A–E, Anthraquinone-γ-Pyrones Discovered from Marine-Derived Actinomycetospora sp. Bacterium
Year: 2025
Type: article
Abstract: Facilitated by LC–MS–PCA metabolomics methods and effective molecular networking for strain prioritization and dereplication, five new anthraquinone-γ-pyrones, actinomycetoquinones A–E ( 1 – 5 ), were isolated from a marine-derived Actinomycetospora sp. bacterium. The structures of 1 – 5 were elucidated by analysis of their HRMS and NMR spectroscopic data. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Actinomycetoquinone C exhibited antibacterial activity against methicillin-resistant S. aureus (MRSA) and E. coli with MIC values of 1 and 4 μg/mL, respectively.
Source: Journal of Natural Products
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: National Institutes of Health, BioXFEL Science and Technology Center, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Research Resources, Division of Biological Infrastructure, Center for Scientific Review, National Science Foundation Graduate Research Fellowship Program
OpenAlex ID: W4414498603