Work

Treatment-related fluctuation of Guillain-Barré syndrome associated with positive autoantibodies: a pediatric case report

Year: 2025

Type: article

Abstract: Guillain–Barre syndrome (GBS) is an acute inflammatory polyneuropathy usually considered as a post-infectious autoimmune disease. It is generally monophasic, but treatment related fluctuation (TRF) and recurrences could occur. The main challenge is to differentiate TRF from acute onset chronic idiopathic demyelinating polyneuropathy (A- CIDP). These entities have different outcomes and prognosis, thus the importance of a thorough workup. Genetic and/or immunological host factors may play an important role. In this report, we describe a case of TRF_GBS associated with positive anti-GAD (Glutamate decarboxylase) and anti-VGKC (canals potassium voltages depended) autoantibodies in an 11-year-old boy. With a focus on management and differential work up. Through this case report, we aim to raise awareness among healthcare providers about this rare but potentially severe entity.

Source: Journal of Carcinogenesis

DOI: 10.64149/j.carcinog.24.3.616-618

Authors: Azza Harbi, Sameh Mabrouk, Selsabil Nouir, Safa Hannechi, Hajer Mokni, Houda Ajmi

Institutions: Hôpital Sahloul, University of Sousse

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500