Comparison of Refractive Outcomes Between Small Lenticule Extraction Using a 500 KHz and a 2 MHz Femtosecond Laser
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background/Objectives: The aim of this study was to compare the efficacy of correcting myopia and myopic astigmatism between small incision lenticule extraction (SMILE) surgery performed using VisuMax 500 and that using VisuMax 800. Methods: Patients who underwent myopia correction using either VisuMax 500 (493 eyes of 249 patients) or VisuMax 800 (169 eyes of 85 patients) employing the nomogram of VisuMax 500 were enrolled in this retrospective case–control study. At 2 months after the operation, the percentage of eyes achieving a postoperative uncorrected distance visual acuity (UDVA) of 20/20 and residual refractive error were compared between the two groups. Additionally, the percentage of eyes with refractive astigmatism angle of error within ±15° and the mean absolute angle of error were analyzed. Results: In the VisuMax 500 and 800 groups, 99% and 97% of eyes achieved a postoperative UDVA of 20/20, respectively. Postoperative residual astigmatism was similar between the two groups, but residual myopia was significantly lower in the VisuMax 800 group (−0.09 ± 0.50 cylinder diopters [CD]) compared to the VisuMax 500 group (−0.21 ± 0.49 CD; p-value = 0.005). Additionally, 84% of eyes in the VisuMax 800 group achieved astigmatism correction within ±15° of the intended meridian, significantly outperforming the 71% in the VisuMax 500 group (p-value = 0.002), with a significantly smaller mean absolute angle of error (8.3 ± 12.2° and 14.1 ± 20.1°; p-value < 0.001). Conclusions: Both VisuMax 500 and VisuMax 800 effectively corrected myopia. However, in terms of the accuracy of astigmatism axis correction, VisuMax 800 demonstrated superior precision compared to VisuMax 500. This study may be limited by perceived bias associated with evaluating two platforms from the same manufacturer.
Source: Diagnostics
Institutions: Korea University, Korea University Ansan Hospital
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,137
Funders: Seoul National University Bundang Hospital, Korea Medical Device Development Fund, National Research Foundation, Ministry of Trade, Industry and Energy, Ministry of Environment, Ministry of Food and Drug Safety, National Research Foundation of Korea, Ministry of Education, India, Ministry of Science and ICT, South Korea, Commercializations Promotion Agency for R and D Outcomes, Korea Environmental Industry and Technology Institute
OpenAlex ID: W4414512277