Work

A novel strategy for nephritis-associated infections: dual-antibacterial/anti-inflammatory effects of Schiff base

Year: 2025

Type: article

Abstract: . Mechanistic studies revealed that D5 disrupts bacterial membrane integrity, causing leakage of intracellular proteins and DNA. Furthermore, it completely eradicated bacteria within 10 hours at 8 × MIC concentration with a low propensity for resistance induction, and possessed both inhibitory and eradicative effects against biofilms. In an LPS-induced RAW 264.7 macrophage model, D5 significantly downregulated the levels of inflammatory factors including TNF-α, IL-6, IL-1β, and NO. Preliminary druggability assessment confirmed its compliance with Lipinski's rule of five. In summary, D5 combines potent antibacterial, anti-biofilm, and anti-inflammatory activities with an excellent safety profile, positioning it as a promising candidate compound for further development.

Source: RSC Advances

DOI: 10.1039/d5ra05377c

Authors: Yu Zhang, Weiwei Fu, Xiangli Xue

Institution: Qinhuangdao Second Hospital

Language: English

Topic: Antimicrobial agents and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042