Work

Association between serum GDF-15 and hypertension in the third trimester of pregnancy

Year: 2025

Type: article

Abstract: BACKGROUND: To investigate the expression of serum Growth differentiation factor 15 (GDF-15) and examine its correlation with systolic and diastolic blood pressure in third-trimester pregnant women with hypertensive disorders of pregnancy (HDP). METHODS: This cross-sectional study included 60 patients with HDP in the third trimester (HDP group) and 50 healthy pregnant women (control group). Clinical characteristics were collected and serum GDF15 levels were measured. RESULTS: Serum GDF-15 levels were significantly elevated in the HDP group compared to controls. Moreover, Serum GDF-15 levels were positively correlated with both systolic blood pressure and diastolic blood pressure in the HDP group. CONCLUSIONS: Serum GDF‑15 levels may be associated with the severity of HDP.

Source: Journal of Obstetrics and Gynaecology

DOI: 10.1080/01443615.2025.2562204

Authors: Cheng Chen, Qin Li, Yanxiang Wang

Institution: Yangzhou Polytechnic Institute

Language: English

Topic: Pregnancy and preeclampsia studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,390