Work

Impact of glycated hemoglobin (HbA1c) on outcomes in differentiated thyroid cancer with type 2 diabetes mellitus

Year: 2025

Type: article

Abstract: INTRODUCTION: Type 2 diabetes mellitus (T2DM) is a frequent comorbidity in differentiated thyroid cancer (DTC). This study evaluated the impact of glycemic control, particularly glycated hemoglobin (HbA1c) levels, on tumor characteristics and treatment outcomes. MATERIAL AND METHODS: We retrospectively analyzed 302 DTC patients, including 58 (19.2%) with T2DM. Baseline demographic, clinical, and pathological data were collected. Treatment response was assessed as per American Thyroid Association (ATA) guidelines. Logistic regression identified predictors of non-excellent response, and a subgroup analysis was performed among diabetic patients stratified by HbA1c (< 7% vs. ≥ 7%). RESULTS: T2DM patients were older (p < 0.001), with more bilateral tumors (p = 0.047) and higher tumor foci (p = 0.039). Other tumor features were similar between groups. In multivariate analysis, both HbA1c[odds ratio (OR): 1.307, 95% confidence interval (CI): 1.014-1.683, p = 0.038) and lymph node metastasis (OR: 3.932, 95% CI: 1.000-15.464, p = 0.050] independently predicted non-excellent response. Among diabetics, HbA1c ≥ 7% was associated with higher non-excellent response rates (p = 0.030). CONCLUSION: Poor glycemic control, rather than T2DM itself, was linked to suboptimal treatment response. HbA1c may serve as a simple prognostic marker in diabetic patients with DTC.

Source: Endokrynologia Polska

DOI: 10.5603/ep.107896

Authors: Merve Çatak, Zeynep Çetin, Özden Özdemir Başer, Asım Kocabay

Institutions: Tokat Gaziosmanpaşa Üniversitesi, Amasya Üniversitesi, Dokuz Eylül University, Ministry of Health

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $539