Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases
Year: 2026
Type: article
Study design: Observational Study
Source: Nature Immunology
Authors: Byunghee Koh, Shani T. Gal Oz, Ryota Sato, Hung N. Nguyen, Garrett Dunlap, Christopher Mahony, Chrissy Bolton, Accelerating Medicines Partnership (AMP) RA/SLE Network, Lucy R. Wedderburn, Adam P. Croft, Laura Donlin, Melanie H. Smith, Soumya Raychaudhuri, Ilya Korsunsky, Deepak A. Rao, Michael B. Brenner
Institutions: Brigham and Women's Hospital, Harvard University, Broad Institute, Massachusetts Institute of Technology, Tanabe Pharma Corporation (Japan), University of Birmingham, University of Oxford, Kennedy Institute of Rheumatology, University College London, Great Ormond Street Hospital, NIHR Great Ormond Street Hospital Biomedical Research Centre, Hospital for Special Surgery, National Institute for Health and Care Research, NIHR Birmingham Biomedical Research Centre, Weill Cornell Medicine
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: George Gund Foundation, National Institute for Health and Care Research, Yükseköğretim Kurulu, Mitsubishi Tanabe Pharma Corporation, National Institutes of Health, Medical Research Council, Birmingham Biomedical Research Centre, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state, Tissue-resident CD8+ memory T cell and fibroblast cross-talk in juvenile idiopathic arthritis, G9000247532, Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC), Immunologic Mechanisms and Rheumatic Diseases, Joint Biology Consortium Resource-based Center, Differentiation of immune cells and fibrobalsts in inflamed tissue in RA and SLE, Regulation of T helper cell functions by aryl hydrocarbon receptor, Using high dimensional molecular data to decipher gene dynamics underlying pathogenic synovial fibroblasts, Predicting the impact of genetic variants, genes and pathways on human Disease, G932915660
OpenAlex ID: W4414515808