Work

Pyrido-indole-one hybrids as potential anticancer agents against breast carcinoma: development of Ru( ii )-catalyzed annulation of indole-2-carboxamides, biological screening and molecular docking studies

Year: 2025

Type: article

Abstract: values of 7.96 ± 0.04 μM and 7.18 ± 0.32 μM in normal HEK-293 kidney cells and BEAS-2B lung cells respectively, indicating ∼10-fold preference for highly aggressive MDA-MB-231 breast cancer cells. Further analyses demonstrated that compound 9c effectively induces cell cycle arrest in MCF-7, 4T1 and MDA-MB-231 breast cancer cells, subsequently leading to a dose-dependent increase in apoptotic cell death. In addition, compound 9c also attenuated the formation of three-dimensional multicellular tumor spheroids (MCTSs), indicating its potential to hinder spheroid development. The molecular docking analysis further elucidates the binding affinity of 9c toward epidermal growth factor receptor (EGFR). As a result, the active hybrid 9c demonstrates strong potential in engaging key cancer-related pathways, further emphasizing its significance in the advancement of next-generation anticancer therapeutics.

Source: RSC Advances

DOI: 10.1039/d5ra06548h