The multiomics blueprint of the individual with the most extreme lifespan
Year: 2025
Type: article
Abstract: Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.
Source: Cell Reports Medicine
Authors: Eloy Santos-Pujol, Aleix Noguera-Castells, Marta Casado-Pelaez, Carlos A. García-Prieto, Claudia Vasallo, Ignacio Campillo-Marcos, Carlos Quero-Dotor, Eva Crespo-García, Alberto Bueno-Costa, Fernando Setién, Gerardo Ferrer, Veronica Davalos, Elisabetta Mereu, Raquel Pluvinet, Carles Arribas, Carolina de la Torre, Francisco Villavicencio, Lauro Sumoy, Isabel Granada, Natalie S. Coles, Pamela Acha, Francesc Solé, Mar Mallo, Caterina Mata, Sara Peregrina, Toni Gabaldón, Marc Llirós, Meritxell Pujolassos, Robert Carreras-Torres, Aleix Lluansí, Librado Jesús García-Gil, Xavier Aldeguer, Sara Samino, Pol Torné, Josep Ribalta, Montse Guardiola, Núria Amigó, Oscar Yanes, Paula Martínez, Raúl Sánchez-Vázquez, Maria A. Blasco, Jose Oviedo, Bernardo Lemos, Julia Rius-Bonet, Marta Torrubiano, Marta Massip-Salcedo, Kamal A. Khidir, Thong Huy Cao, Paulene A. Quinn, Donald J.L. Jones, Salvador Macip, Eva Brigos-Barril, Mauricio Moldes, Fabio Barteri, Gerard Muntané, Hafid Laayouni, Arcadi Navarro, Manel Esteller
Institutions: Josep Carreras Leukaemia Research Institute, Universitat de Vic - Universitat Central de Catalunya, Centro de Investigación Biomédica en Red, Centro de Investigación Biomédica en Red de Cáncer, Barcelona Supercomputing Center, Universitat Pompeu Fabra, Pasqual Maragall Foundation, Barcelonaβeta Brain Research Center, Institut de Biologia Evolutiva, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat de Barcelona, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Institució Catalana de Recerca i Estudis Avançats, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Enfermedades Infecciosas, Institut d'Investigació Biomèdica de Girona, Institut de Recerca Sant Joan de Déu, Universitat de Girona, Hospital Universitari de Girona Doctor Josep Trueta, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Institut de Recerca Biomèdica Catalunya Sud, Universitat Rovira i Virgili, Spanish National Cancer Research Centre, Fundación Humanismo y Ciencia, Harvard University, University of Arizona, Universitat Oberta de Catalunya, University of Leicester, University of Raparin, Glenfield Hospital, University Hospitals of Leicester NHS Trust, National Institute for Health and Care Research, Leicester Royal Infirmary, Consejo Superior de Investigaciones Científicas, Barcelona Biomedical Research Park, Centre for Genomic Regulation, Institut Pere Mata, Centro de Investigación Biomédica en Red de Salud Mental
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
Funders: Fundación Cellex, Ministerio de Ciencia, Innovación y Universidades, Centres de Recerca de Catalunya, National Institute for Health and Care Research, European Commission, Generalitat de Catalunya, Institució Catalana de Recerca i Estudis Avançats, Universitat Oberta de Catalunya, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III, European Regional Development Fund, Agencia Estatal de Investigación, NIHR Leicester Biomedical Research Centre
Awards: G1105844351, G1175115578, G1341303, G1445677998, G148081399, G1568616013, G1622782223, G1647147122, G1784723005, G1968300042, G2038104832, G2064873908, G210041235, G2158185920, G2262748287, G2355262757, G2462415295, G2496480614, G2601397997, G2672435700, G270533271, G288263039, G2979234808, G3005324705, G300979063, G34346518, G3480869486, G3546882995, G3681454997, G3761084913, G3802665900, G3941027461, G3992582002, G4042783231, G410571670, G425668148, G4287402861, G4442677895, G451917667, G4526231891, G4731613563, G4845145500, G4848019596, G491712853, G5080475149, G5195188938, G5404395142, G5539308778, G5635532810, G5806516646, G5852091828, G5967599077, G6232245676, G6238336926, G624877701, G6656126374, G69051668, G6959961028, G7084143925, G717256432, Efectos del ayuno intermitente sobre el envejecimiento orgánico en mujeres posmenopáusicas, G7466406081, G7551257413, G775295145, G7805626310, G7863371703, TUMOUR-HOST INTERACTIONS IN LIVER CANCER OF CHILDHOOD AND ADULTS, G8140489984, G8497050386, G8637226926, G8696694383, G929308097
OpenAlex ID: W4414516739