Investigating the ABTS-based antioxidant potential and antiproliferative activity of pulp, skin and seeds extracts from Nephelium lappaceum, Manilkara zapota, and Meliccocus oliviformis on human prostate and colon cancer cells
Year: 2025
Type: article
Abstract: Despite significant advancements in cancer treatments, cancer remains the second leading cause of death worldwide, creating a pressing need for effective and non-toxic therapies. Plant bioactive compounds, particularly phenolic acids, have shown promising antioxidant and anticancer properties. In this study, we investigated the antioxidant potential and antiproliferative activity of methanolic extracts obtained from the skin, pulp, and seeds of three exotic fruits commonly consumed in Mexico: Manilkara zapota , Nephelium lappaceum , and Meliccocus oliviformis . The antioxidant activity was assessed using the ABTS radical scavenging assay, and total phenolic content was quantified by a modified Folin-Ciocalteu method. Most extracts exhibited significant ABTS radical scavenging capacity, with the highest phenolic content detected in the skin and seeds of N. lappaceum . and M. oliviformis . Cytotoxic and antiproliferative effects were evaluated on human colon (HCT116) and prostate (DU145) cancer cell lines. The skin of N. lappaceum and the seeds of M. zapota and M. oliviformis showed strong antiproliferative activity. These findings highlight the therapeutic potential of underutilized fruit by-products and support further investigation into their bioactive constituents as complementary candidates for cancer treatment. • Skin, pulp and seeds extracts of M. oliviformis , M. zapota and N. lappaceum show different ABTS-based antioxidant potentials. • Among these extracts, the skin and the seeds of M. oliviformis and N . lappaceum are particularly enriched in total phenols. • N . lappaceum skin and M . zapota and M . oliviformis seeds show strong antiproliferative and cytotoxic effects on cancer cells.
Institutions: Universidad Juárez Autónoma de Tabasco, Universidad Nacional Autónoma de México, Benito Juárez Autonomous University of Oaxaca, Centre National de la Recherche Scientifique, Université de Lille, Unité de Glycobiologie Structurale et Fonctionnelle, Inserm, Miniaturisation pour la Synthèse, l'Analyse et la Protéomique, CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,700
OpenAlex ID: W4414517514