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Aldehydes as CO Releasing Molecules: In Situ and Ex Situ Giese Reactions and Palladium-Catalyzed Aminocarbonylations

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide We report the adoption of a two-chamber reactor making use of aliphatic aldehydes in the role of CO releasing molecules (CORMs). Upon photocatalytic conditions, an acyl radical (RCO • ) was first formed, prone to lose CO. The resulting alkyl radical was employed in the in situ conjugate addition onto a Michael acceptor (in the first chamber), and the released CO was employed in ex situ palladium-catalyzed aminocarbonylations (in the second chamber) to ensure a 100% atom-economical reaction.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c03618

Authors: Elena Cassera, Maurizio Fagnoni

Institution: University of Pavia

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Dipartimenti di Eccellenza, Ministero dell'Università e della Ricerca, NextGenerationEU