Work

Serum hepcidin as a biomarker of treatment response in Gaucher disease

Year: 2025

Type: article

Abstract: Gaucher disease (GD) is a lysosomal disorder associated with hyperferritinemia and altered hepcidin levels. This study evaluated the effect of GD-specific treatment on serum hepcidin and interleukin-6 (IL-6) in seven treatment-naïve Brazilian patients with type 1 GD. Concentrations were measured before and after initiation of treatment. Hepcidin levels significantly decreased and IL-6 showed a downward trend. These results suggest that hepcidin may also exert endocrine effects in GD-related iron metabolism.

Source: Molecular Genetics and Metabolism Reports

DOI: 10.1016/j.ymgmr.2025.101255

Authors: Tiago Koppe, Franciele C. Pinheiro, Marina Siebert, Suelen Basgalupp, Liane E. Daudt, Ida Vanessa D. Schwartz

Institutions: Universidade Federal do Rio Grande do Sul, Universidade Federal de Santa Maria, Hospital de Clínicas de Porto Alegre

Language: English

Topic: Lysosomal Storage Disorders Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400