Primary bladder signet ring cell adenocarcinoma in a young male with Lynch Syndrome
Year: 2025
Type: article
Study design: Case Report
Abstract: A 32-year-old male with Lynch Syndrome and a history of colon cancer status post total proctocolectomy was found to have invasive high-grade carcinoma with signet ring cell morphology on tissue sampling of the bladder neck following transurethral resection of a bladder tumor (TURBT). The patient subsequently underwent an open cystoprostatectomy and completion proctectomy. Final pathology of the prostate, bladder, and bladder augment confirmed the diagnosis of signet ring cell adenocarcinoma (SRCC) of the bladder. Given its rarity, this case illustrates the challenges of managing an aggressive bladder cancer and underscores the importance of considering appropriate screening strategies in high-risk populations.
Source: Urology Case Reports
Authors: James Um, Aidan Kennedy, Christopher D. Jaeger, Nikta Rezakahn Khajeh, Paul Alan Horning, Reenal Patel, Kanika Arora, Adam J. Gadzinski
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,160
OpenAlex ID: W4414518154