Work

Case Report: A 14-year-old boy with recurrent pancreatitis and autism—response to steroid and rituximab therapy

Year: 2025

Type: article

Abstract: We report the case of a 14-year-old boy with a history of recurrent pancreatitis, autism, and learning disabilities who presented with non-bilious vomiting, epigastric pain, and a progressively enlarging abdominal mass. He was diagnosed with IgG4-related autoimmune pancreatitis. Initial corticosteroid therapy achieved only temporary remission, with disease relapse occurring after 4 months. Rituximab was subsequently introduced, resulting in sustained disease control by depleting B lymphocytes and reducing disease flares, consistent with previous reports. The patient has remained clinically stable for 1 year. This case highlights the clinical presentation, diagnostic challenges, and therapeutic considerations of this rare condition.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1594539

Authors: Yu-An Lu, Chieh-Chung Lin, Yen-Chu Huang

Institutions: Taichung Veterans General Hospital, Kaohsiung Veterans General Hospital, Chung Shan Medical University, National Chung Hsing University

Language: English