Novel Synthesis and Structural Characterization of Venetoclax Impurities via [2,3] Meisenheimer Rearrangement
Year: 2025
Type: article
Abstract: Venetoclax (1), a BCL-2 inhibitor, is extensively used in the treatment of chronic lymphocytic leukemia, small lymphocytic lymphoma, and acute myeloid leukemia. In this study, we report the synthesis of a novel venetoclax impurity, VHA (3), via a [2,3] Meisenheimer rearrangement of VNO (2). Upon heating, VHA (3) undergoes further rearrangement, resulting in the formation of [1,2] Meisenheimer rearranged product VHA (4). The structures of these impurities were confirmed using 1H NMR, HPLC, and mass spectrometry. This synthetic approach provides an efficient method for synthesising Venetoclax impurities VHA (3) and VHA (4).
Source: Indian Journal of Chemistry
Authors: Dr. Mohan T P, Dr. selvakumar B, Dr. Ashok Kumar N B, Balaraju B
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4414520714
FWCI:
Cites:
Cited by:
Related to: