Work

Rapid diagnosis and targeted therapy of Chlamydia psittaci pneumonia: The clinical value of quantitative metagenomic next-generation sequencing

Year: 2025

Type: article

Abstract: Chlamydia psittaci (C. psittaci) pneumonia poses significant challenges for early diagnosis due to its non-specific clinical presentation and imaging characteristics. Delayed etiological diagnosis and inappropriate treatment often lead to disease exacerbation. In this case, the patient's initial empirical treatment proved ineffective, and the condition worsened. The diagnosis of C. psittaci infection was ultimately confirmed through quantitative metagenomic next-generation sequencing (Q-mNGS™). Following targeted azithromycin therapy, the patient's symptoms and imaging findings markedly improved. This case underscores the clinical value of metagenomic next-generation sequencing (mNGS) in the early diagnosis and targeted treatment of C. psittaci pneumonia in non-immunocompromised individuals.

Source: Indian Journal of Medical Microbiology

DOI: 10.1016/j.ijmmb.2025.100984

Authors: Wen Wen, Ziling Zeng, Shuang Liang, Yun Zhang, Jun Deng

Institutions: Southwest Medical University, Affiliated Hospital of Southwest Medical University

Language: English

Topic: Bacterial Identification and Susceptibility Testing

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,210