Work

Mechanisms of Ferroptosis and Emerging Links to the Pathology of Metabolic Disorders

Year: 2025

Type: article

Abstract: : Ferroptosis, a unique form of programmed cell death characterized by lipid peroxidation and iron accumulation, has emerged as a critical factor in the development and progression of metabolic disorders. This review explores the role of ferroptosis in various pathological conditions, including obesity, type-2 diabetes, renal and adrenal injury, and cardiometabolic complications. The interplay between oxidative stress, lipid metabolism, and ferroptosis highlights its contribution to cellular dysfunction and tissue damage in these metabolic disorders. Furthermore, the potential of nutritional and pharmacological interventions to modulate ferroptosis pathways is examined, with a focus on antioxidants, iron chelators, and dietbased strategies. Understanding the mechanism and therapeutic implications of ferroptosis provides a foundation for an innovative approach to combat metabolic disorders. Future research is essential to uncover biomarkers, refine therapeutic strategies, and translate these findings into clinical practice.

Source: Current Indian Science

DOI: 10.2174/012210299x394730250912071440

Authors: Bhoopendra Singh, Nidhi Srivastava, Ankita Sharma

Institution: National Institute of Pharmaceutical Education and Research

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Council of Science and Technology, U.P.