Case Report: Dropped head syndrome as a main clinical sign of suspected myasthenia gravis in two dogs
Year: 2025
Type: article
Study design: Case Report
Abstract: Drop head syndrome (DHS), characterized by pronounced cervical ventroflexion, is a clinical syndrome that can be found associated with neuromuscular disorders, particularly myasthenia gravis. In this case series, we describe two dogs, an 8-year-old Basset Hound and a 3-year-old Zwergpinscher, presenting with DHS as the main clinical sign. In both cases, a presumptive diagnosis of myasthenia gravis was made and were empirically treated with pyridostigmine. Telephone follow-ups at 6 and 4 months after diagnosis, respectively, were consistent with clinical remission. These cases highlight the diagnostic challenges of DHS, emphasizing the need for thorough evaluation to exclude numerous differential diagnoses. In cases where myasthenia gravis is strongly suspected despite negative tests, trial treatment with anti-cholinesterase drugs may be considered, with caution to avoid potential side effects.
Source: Frontiers in Veterinary Science
Authors: Henry Mendo Reyes, Greta Galli, Erica Fiorentino, Anna Gardini, Beatrice Bravaccini, Marika Menchetti
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4414533888