Efficacy of oral tofacitinib in moderate to severe alopecia areata, totalis and universalis at the tertiary care hospital, Karachi
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: OBJECTIVE: To evaluate the effectiveness and safety of oral tofacitinib in treating patients with different forms of alopecia. METHODS: The prospective, interventional, open-label study was conducted at the Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, from November 2023 to April 2024, and comprised cases of alopecia areata, totalis and universalis. Tofacitinib 5mg twice daily was prescribed, and the Severity of Alopecia Tool score was evaluated at baseline, and then again at 6 weeks, 12 weeks and 24 weeks. Data was analysed using SPSS 23. RESULTS: Of the 30 subjects with mean age 26.53±4.77 years (range: 19-36 years), 15(50%) were males and 15(50%) were females. The mean Severity of Alopecia Tool score at baseline was 88.41±11.59, which decreased to 74.75±13.88 at 6 weeks, 58.51±20.96 at 12 weeks, and 45.88±23.63 at 24 weeks. Overall, 24(80%) patients showed improvement at 24 weeks in terms of hair regrowth. No adverse events were noted in any patient. CONCLUSIONS: The efficacy and safety of tofacitinib in the treatment of alopecia areata showed promising results, and it could be a viable treatment option for alopecia.
DOI: 10.47391/jpma.21658
Institution: Jinnah Postgraduate Medical Center
Language: English
Topic: Hair Growth and Disorders
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $650
OpenAlex ID: W4414535151
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