Congenital cytomegalovirus infection: clinical findings and outcome in patients from a tertiary paediatric hospital in Florianópolis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Cytomegalovirus (CMV) is a widely disseminated virus, capable of remaining latent and reactivating, with high global seroprevalence. In Brazil, seroprevalence exceeds 95%, with primary infections predominating in childhood. Objective: To describe the clinical profile at birth and outcome at 12 months of age of patients diagnosed with congenital cytomegalovirus infection in a reference pediatric hospital in Florianópolis from 2017 to 2022. Methods: This was a retrospective, observational and descriptive study with secondary data analysis. The research was approved by the Human Research Ethics Committee. Results: Of the 20 cases included in the study, 12 (60%) were female and all were white coloured. 14/17 (82.3%) of the cases were full-term births and 14/16 (87.5%) had a low birth weight for gestational age. Jaundice was identified in 7/13 (53.8%), microcephaly in 5/18 (27.7%), conjugated hyperbilirubinemia in 5/8 (62.5%) and intracranial calcifications in 9/20 (45%) records. 6/20 (30%) cases failed the neonatal hearing screening and 5/20 (25%) presented bilateral loss of brainstem auditory evoked potential. At 12 months of age, bilateral hearing loss and microcephaly were found in 5/8 (62.5%) and 7/13 (53.8%) cases respectively. Conclusion: Low birth weight for gestational age, jaundice and microcephaly were prevalent changes. Intracranial calcifications were the most common neuroimaging finding. Important late sequelae were present at 12 months of age.
Institution: Universidade Federal de Santa Catarina
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414536190