Work

The action of Palbociclib on the Cell Cycle of Head and Neck Squamous Cell Carcinoma: A Systematic Review

Year: 2025

Type: review

Abstract: This study evaluates the action of Palbociclib in the cell cycle of HPV-negative head and neck squamous cell carcinoma. Initially approved for HER2- and HR + breast cancer. Palbociclib induces cellular senescence, increases the efficacy of Cetuximab, restores p16 function and decreases phosphorylated Rb, suggesting an improvement in survival in both cancers.

Source: Brazilian Journal of Oncology

DOI: 10.1055/s-0045-1811626

Authors: Maria Eduarda Bertolazzi Teixeira, João Pedro Fabrini da Silva, Ana Cristina da Silva do Amaral Herrera

Institution: Pontifícia Universidade Católica do Paraná

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414536821