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Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms

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Year: 2025
Type: article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5c01736
Authors: Farman M. Abbasi, Konica Porwal, Subhashis Pal, Shivani Sharma, Sreyanko Sadhukhan, Swati Rajput, Chirag Kulkarni, Shubham K. Talware, Mohammad I. Siddiqi, Divya Chauhan, Jiaur R. Gayen, Naibedya Chattopadhyay, Sanjay Batra
Institutions: Central Drug Research Institute, Academy of Scientific and Innovative Research, Council of Scientific and Industrial Research
Language: English

Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: closed

Funders: Department of Biotechnology, Ministry of Science and Technology, India, Department of Science and Technology, Ministry of Science and Technology, India, Council of Scientific and Industrial Research, India, University Grants Commission, Central Drug Research Institute
Awards: G2096225123, G8857635299
OpenAlex ID: W4414542135
FWCI: 1.305
Cites: 61
Cited by: 5
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