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Case Commentary: Successful use of olorofim for the treatment of multi-drug-resistant Lomentospora prolificans infection in a child

Year: 2025

Type: editorial

Abstract: ABSTRACT Lomentospora prolificans is a multi-drug-resistant filamentous fungus that can cause invasive disease in both immunocompromised and immunocompetent hosts. Current treatment options are limited. Olorofim is an investigational antifungal that demonstrates activity against several different molds, including many that are resistant to other antifungals. The case presented by Fortini et al. (Antimicrob Agents Chemother 69:e00602-25, 2025, https://doi.org/10.1128/aac.00602-25 ) describes the successful use of olorofim treatment in an 8-year-old who suffered from Lomentospora prolificans tendonitis, synovitis, and osteomyelitis.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01072-25

Author: Nathan P. Wiederhold

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414542907

Cites: 38

Cited by: 2

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