Work

The fibroblast-driven melanoma/Treg vitiligo mouse model is effectively suppressed by IFNγ blocking antibody

Year: 2025

Type: article

Abstract: The use of immunosuppressive drugs for vitiligo treatment carries a potential risk of increased infection, whereas IFNγ bispecific antibodies represent an alternative therapeutic strategy. Researchers employing the melanoma/Treg vitiligo mouse model identified a critical role of dermal fibroblasts during the progressive phase of vitiligo. These fibroblasts respond to IFNγ and recruit CD8 + T cells, a mechanism that also contributes to the bilateral symmetrical depigmentation commonly observed in vitiligo patients. To evaluate the suitability of this model as a platform for developing fibroblast-targeted IFNγ bispecific antibodies, mice were administered regular injections of IFNγ monoclonal antibodies. The IFNγ monoclonal antibody treatment significantly suppressed vitiligo progression in the melanoma/Treg model. Owing to its advantages-including straightforward induction, multi-antigen specificity, and the demonstrated efficacy of IFNγ blocking antibodies, the melanoma/Treg vitiligo mouse model is a robust platform for advancing the development of fibroblast-targeted IFNγ bispecific antibodies.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1677626

Authors: Yuhua Xie, Jun Cui, Yanhua Lu, Yingxue Du, Jianmin Chang

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Hospital, National Institute of Biological Sciences, Beijing

Language: English

Topic: melanin and skin pigmentation

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801