Work

Pleuroparenchymal Fibroelastosis With Progressive Bronchiectasis and Apical Pneumothoraces in a Patient With Severe Chronic Obstructive Pulmonary Disease and Chronic Pseudomonas Colonization: A Case Report

Year: 2025

Type: article

Abstract: Pleuroparenchymal fibroelastosis (PPFE) is a rare condition of progressive interstitial lung disease marked by bilateral upper lobe pneumothoraces and fibrosis. We present the case of a 73-year-old female with a background of bronchiectasis, chronic obstructive pulmonary disease (COPD), and long-standing Pseudomonas colonization, who presented with progressive shortness of breath, chest tightness, and cough. Imaging revealed bilateral apical pneumothoraces and progressive bronchiectatic and fibrotic changes. Sputum cultures grew Escherichia coli, Achromobacter species, and Candida. A diagnosis of PPFE was made based on characteristic clinical and radiographic findings. After discussion in the multidisciplinary team (MDT) and confirmation of the diagnosis, given the non-progressive nature of the pneumothoraces and her poor functional reserve, conservative management was advised. This case highlights the complexity of managing advanced respiratory disease in a severely malnourished patient with chronic infection and multiple comorbidities.

Source: Cureus

DOI: 10.7759/cureus.93247

Authors: Shayekh Ferdoush, Ridwan Shahnewaz, Mustain Jawad, Morad Albarouni, Farmina Ahmed

Institutions: University Hospitals Bristol and Weston NHS Foundation Trust, Weston General Hospital, Bangladesh Medical University

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414553040