Work

Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC

Year: 2025

Type: article

Source: Angewandte Chemie

DOI: 10.1002/ange.202508518

Authors: Hannah T. Rosen, Kelvin Li, Christian E. Stieger, Erin L. Li, Brynne Currier, Scott M. Brittain, Francisco J. Garcia, Diana C. Beard, Michael D. Jones, Sandra Haenni‐Holzinger, Dustin Dovala, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel K. Nomura

Institutions: Innovative Genomics Institute, University of California, Berkeley, Novartis (Switzerland), Novartis Institutes for BioMedical Research

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: closed

Funders: National Science Foundation, Mark Foundation For Cancer Research, Barbara and Gerson Bakar Foundation, National Institutes of Health, Novartis Institutes for BioMedical Research, National Cancer Institute

Awards: G2834251479, MFB: Developing Next-Generation Approaches to Targeted Protein Degradation, G9000205671, Tackling Undruggable Cancer Targets using Chemoproteomic Platforms

OpenAlex ID: W4414553060

FWCI:

Cites: 51

Cited by:

Related to: