Work

Pregnancy-dependent cardioprotection via GPER activation in Dahl salt-sensitive rats with superimposed preeclampsia

Year: 2025

Type: article

Abstract: In this work, GPER (G protein-coupled estrogen receptor) was investigated as a novel therapeutic target for managing cardiovascular complications in preeclampsia. Activation of GPER by the selective agonist LNS8801 significantly improved cardiac function during pregnancy, with no effect on virgin animals, suggesting a pregnancy-specific impact. It also reduced blood pressure in pregnant Dahl SS/Jr rats with superimposed preeclampsia.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00262.2025

Authors: Allan K. N. Alencar, Kenneth F. Swan, Mistina M. Manoharan, Christopher A. Natale, Sarah H. Lindsey, Gabriella C. Pridjian, Michael R. Garrett, Carolyn L. Bayer

Institutions: Tulane University, VentureWell, University of Mississippi Medical Center

Language: English

Topic: Pregnancy and preeclampsia studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Mississippi IDeA Network of Biomedical Research Excellence, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1193003524, G1740413872, G1912478952, G4542591229, G5671849667, G5914149352, G5993252580, G6050258521, G659735559, G717771152, Placental Functional Imaging to Predict Preeclampsia Therapeutic Outcomes, Mississippi INBRE

OpenAlex ID: W4414553763

FWCI:

Cites: 44

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