Alpha cells transdifferentiate into delta cells during the progression of autoimmunity in nondiabetic NOD mice
Year: 2025
Type: article
Abstract: The NOD mouse is widely used as an T1D animal model. Although the mice have the same genetic background, approximately 20% of female NOD mice do not develop diabetes. In this study, we reveal that alpha cells dedifferentiate and then transdifferentiate into delta cells during the progression of autoimmunity in nondiabetic NOD mice. The increased delta cells secrete more somatostatin, which inhibits alpha cell secretion of glucagon, thereby potentially attenuating the increase in blood glucose levels in these mice.
Authors: Zhehui Li, Xinyun Wu, Qi Kang, Qi Ren, Yi Zhang, Yi Zhang, Quanwen Jin, F. Susan Wong, Mingyu Li
Institutions: Xiamen University, Fujian Medical University, Cardiff University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G3067626700, G3842893016
OpenAlex ID: W4414554099