Work

Diurnal function and expression of aquaporins in the mouse kidney

Year: 2025

Type: article

Abstract: Mouse plasma and urine osmolalities are greater in the middle of the active period, when food/water intake, gut reabsorption, glomerular filtration rate, and urine flow are increased. There were time-of-day effects on aquaporin mRNA, and increased nephron abundance of aquaporins during the middle of the active period. As the kidneys excrete the excess solutes, the medullary interstitial gradient and aquaporins are primed to concentrate the urine and return the plasma osmolality to a steady state.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00162.2025

Authors: Hung Nguyen, Nha Van Huynh, Kelly A. Hyndman

Institutions: University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, School of Medicine, University of Alabama at Birmingham, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G4326489877, G4489817407, Lysine Acetylation and the Regulation of Vasopressin/Aquaporin System in the Principal Cell