Work

Systematic review of c-met as a prognostic indicator in esophageal cancer patients: a meta-analysis study

Year: 2025

Type: review

Study designs: Systematic Review, Meta-Analysis

Abstract: OBJECTIVES: To evaluate c-met expression as a reliable prognostic indicator for survival in esophageal cancer patients. METHODS: Eligible articles from relevant studies or databases were retrieved via systematical search. The association between c-met expression and survival results was evaluated by pooled effect in esophageal cancer patients. A fixed-effects or random-effects model was used to calculate the pooled risk ratios (RRs) and corresponding 95% confidence intervals (CIs). RESULTS: 13 studies were up to the selection criteria. Our meta-analysis indicated that c-met positive expression correlated with lower overall survival (RR = 0.40; 95%CI: 0.25-0.63), disease-free-survival (RR = 0.30; 95%CI: 0.21-0.44), disease specific survival (RR = 0.53; 95%CI: 0.35-0.80) in esophageal cancer patients. CONCLUSION: C-met positive expression indicates a poor prognosis in esophageal cancer patients. Further studies are required to confirm our result.

Source: Discover Oncology

DOI: 10.1007/s12672-025-03398-y

Authors: Zipu Yu, Guofei Zhang, Gang Shen

Institutions: Second Affiliated Hospital of Zhejiang University, Zhejiang University

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,690