Impact of Ozone Exposure on Oral Microbiome: A Controlled, Randomized, Crossover Trial
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: ) by 0.36 L, and peak expiratory flow (PEF) by 0.81 L, while observed species richness (Sobs), abundance-based coverage estimator (Ace), and chao indices (Chao) decreased by 21.83, 22.24, and 21.87%, respectively. Males exhibited greater sensitivity to ozone exposure than females, reflected in both reduced lung function and alterations in the oral microbiome. The altered microbiome was mainly enriched in metabolic pathways. Among the microbiome, Treponema medium exhibited a significant correlation and mediating effect on ozone-induced lung function impairment, which may serve as a sensitive indicator of changes in lung function. These findings provide new insights into the health effects caused by ozone exposure.
Source: Environment & Health
Authors: Hao Zhou, Shuyun Jiang, Liying Zhang, Jian Zhao, Tianzong Zhou, Luyun Zhang, Yuliang Ma, Shuhan Liu, Zhengkang You, Fengru Li, Shen Chen, Liping Chen, Qing Wang, Xiumei Xing, Wen Chen, Daochuan Li
Institution: Sun Yat-sen University
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,500
Funder: Key Programme
Award: G5890525259
OpenAlex ID: W4414556203