Work

N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum

Year: 2025

Type: article

Abstract: The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α-synuclein release in vivo in the presence of selective channel inhibitors. Our results revealed that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum.

Source: npj Parkinson s Disease

DOI: 10.1038/s41531-025-01110-z

Authors: Emmanouela Leandrou, Ioanna Chalatsa, Kostas Vekrellis, Evangelia Emmanouilidou

Institutions: National and Kapodistrian University of Athens, Biomedical Research Foundation of the Academy of Athens

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890