Polycystic ovary syndrome: a comprehensive review of pathophysiology, diagnosis, and emerging management strategies
Year: 2025
Type: article
Abstract: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 6-20% of women of reproductive age, characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. Its pathophysiology involves intricate interactions among genetic, epigenetic, metabolic, and environmental factors, with insulin resistance, gut microbiota dysbiosis, and novel biomarkers like anti-Müllerian hormone (AMH) playing pivotal roles. This review provides an in-depth exploration of PCOS etiology, diagnostic challenges, and management strategies, including lifestyle interventions, pharmacological therapies, and emerging approaches like microbiota modulation and microRNA therapies. We also address long-term health risks, such as cardiovascular disease, type 2 diabetes mellitus (T2DM), and mental health challenges, emphasizing personalized and multidisciplinary treatment strategies.
Authors: Mustafa Bashir, Fiza Amin, Huda Amin, Toufeeq Ahmed Teli, Tavseef Ahmad Tali
Institutions: Government Medical College, Government Medical College
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414556415