Work

Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1- b ]thiazoles, Imidazo[1,5- a ]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 Inhibition

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c01067

Authors: Sylvaine Cren, Carina Lotz-Jenne, Thierry Kimmerlin, Julien Pothier, Philippe Risch, Aengus Mac Sweeney, Christoph Joesch, Laetitia Pouzol, Alexia Chavanton-Arpel, Christoph Boss

Institution: Idorsia Pharmaceuticals Ltd (Switzerland)

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W4414559814

FWCI:

Cites: 60

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