Work

Implantable Nongenetic Optoelectronic Biointerfaces for Neuromodulation

Year: 2025

Type: article

Abstract: Electroceuticals are a novel type of therapeutics that employ electrical stimulation to modulate neural circuits and recover impaired physiological functions. Traditional systems using implanted leads as electrode and/or connecting wires pose several clinical challenges, including infection risk, anatomical incompatibilities, and leads dislodgement. Recent progress in optoelectronic biointerfaces is establishing new paradigms for electroceutical intervention by enabling precise, minimally invasive, and nongenetic neuromodulation through light‐driven wireless technologies. In this review, first, the modulation mechanism of representative organic and inorganic semiconductor‐based optoelectronic biointerfaces is demonstrated, which can be designed into flexible and tissue‐conforming architectures. Then, further their capabilities to modulate structures at various levels, including neurons, nerve tissues, and the cerebral cortex are emphasized. Beyond neuromodulation, their promising therapeutic value and translational potential are highlighted, encompassing vision restoration, nerve regeneration, and treatment of Parkinson's disease. Together, these advancements mark a transformative shift toward next‐generation bioelectronic medicine.

Source: Advanced Photonics Research

DOI: 10.1002/adpr.202500176

Authors: Jinglin Ye, Jinwei Huang, Wenyu Nie, Jianming Xu, Xing Sheng, Huachun Wang

Institutions: Sun Yat-sen University, Beijing National Research Center for Information Science and Technology, Tsinghua University

Language: English

Topic: Neuroscience and Neural Engineering

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,070